APREPITANT

N/A

Manufactured by Merck Sharp & Dohme LLC

73,587 FDA adverse event reports analyzed

Last updated: 2026-04-14

About APREPITANT

APREPITANT is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Merck Sharp & Dohme LLC. The most commonly reported adverse reactions for APREPITANT include NAUSEA, FATIGUE, PYREXIA, DIARRHOEA, DYSPNOEA. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for APREPITANT.

Top Adverse Reactions

NAUSEA2,147 reports
FATIGUE1,769 reports
PYREXIA1,589 reports
DIARRHOEA1,542 reports
DYSPNOEA1,508 reports
VOMITING1,474 reports
OFF LABEL USE1,340 reports
ALOPECIA1,274 reports
RASH1,210 reports
HYPERSENSITIVITY1,133 reports
FEBRILE NEUTROPENIA1,045 reports
DECREASED APPETITE1,038 reports
PRURITUS1,019 reports
STOMATITIS991 reports
INFUSION RELATED REACTION972 reports
PAIN955 reports
CONFUSIONAL STATE909 reports
ASTHENIA876 reports
INFECTION874 reports
GASTROINTESTINAL DISORDER852 reports
GENERAL PHYSICAL HEALTH DETERIORATION852 reports
ARTHRALGIA840 reports
MALAISE837 reports
GLOSSODYNIA832 reports
HEPATIC ENZYME INCREASED821 reports
IMPAIRED HEALING812 reports
HAND DEFORMITY809 reports
FOLLICULITIS806 reports
HEADACHE801 reports
NASOPHARYNGITIS795 reports
HELICOBACTER INFECTION794 reports
INSOMNIA785 reports
WEIGHT INCREASED781 reports
SINUSITIS776 reports
LOWER RESPIRATORY TRACT INFECTION771 reports
DUODENAL ULCER PERFORATION767 reports
SYSTEMIC LUPUS ERYTHEMATOSUS765 reports
ABDOMINAL DISCOMFORT761 reports
SWELLING759 reports
JOINT SWELLING758 reports
CONTUSION741 reports
IRRITABLE BOWEL SYNDROME736 reports
SYNOVITIS733 reports
BLISTER732 reports
ILL DEFINED DISORDER726 reports
MUSCLE INJURY714 reports
RHEUMATOID ARTHRITIS710 reports
DRUG INEFFECTIVE705 reports
PERIPHERAL SWELLING701 reports
WOUND693 reports
DISCOMFORT689 reports
PERICARDITIS689 reports
CONDITION AGGRAVATED686 reports
NEUTROPENIA681 reports
ARTHROPATHY678 reports
SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE677 reports
HYPERTENSION671 reports
ANTI CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE668 reports
PEMPHIGUS660 reports
SLEEP DISORDER659 reports
DIZZINESS645 reports
PNEUMONIA628 reports
THROMBOCYTOPENIA621 reports
ABDOMINAL PAIN619 reports
INJURY619 reports
CHEST PAIN561 reports
DRUG INTOLERANCE559 reports
WEIGHT DECREASED546 reports
DEATH531 reports
CONSTIPATION527 reports
URTICARIA519 reports
CONTRAINDICATED PRODUCT ADMINISTERED511 reports
ABDOMINAL PAIN UPPER507 reports
ERYTHEMA492 reports
PARAESTHESIA490 reports
DRUG HYPERSENSITIVITY487 reports
HYPOAESTHESIA484 reports
OEDEMA PERIPHERAL484 reports
ANAEMIA482 reports
PAIN IN EXTREMITY467 reports
THERAPEUTIC PRODUCT EFFECT DECREASED463 reports
WHEEZING462 reports
LIVER DISORDER460 reports
MATERNAL EXPOSURE DURING PREGNANCY445 reports
FIBROMYALGIA444 reports
PRODUCT USE IN UNAPPROVED INDICATION439 reports
DRUG INTERACTION433 reports
ANXIETY420 reports
MEDICATION ERROR416 reports
JOINT RANGE OF MOTION DECREASED415 reports
C REACTIVE PROTEIN ABNORMAL412 reports
PRODUCT USE ISSUE411 reports
MUSCLE SPASMS410 reports
RHEUMATOID FACTOR POSITIVE408 reports
TYPE 2 DIABETES MELLITUS407 reports
ACUTE KIDNEY INJURY403 reports
DRY MOUTH403 reports
MOBILITY DECREASED393 reports
FACET JOINT SYNDROME388 reports
LUNG DISORDER388 reports

Report Outcomes

Out of 17,742 classified reports for APREPITANT:

Serious 88.7%Non-Serious 11.3%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Female10,116 (62.4%)
Male5,983 (36.9%)
Unknown121 (0.7%)

Reports by Age

Age 44990 reports
Age 65463 reports
Age 66451 reports
Age 59414 reports
Age 57409 reports
Age 62397 reports
Age 60389 reports
Age 63386 reports
Age 69386 reports
Age 58377 reports
Age 61377 reports
Age 70373 reports
Age 68346 reports
Age 67341 reports
Age 56311 reports
Age 64309 reports
Age 71293 reports
Age 48280 reports
Age 55278 reports
Age 74274 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Frequently Asked Questions

How many FDA adverse event reports are associated with APREPITANT?

This profile reflects 73,587 FDA FAERS reports that mention APREPITANT. Reporting is voluntary and does not prove that the drug caused any listed event.

Which adverse reactions are most often listed for APREPITANT?

Frequently reported terms in FAERS include NAUSEA, FATIGUE, PYREXIA, DIARRHOEA, DYSPNOEA, VOMITING. Rankings reflect reporting volume in this dataset, not confirmed side effect rates in the general population.

Who manufactures APREPITANT?

Labeling and FAERS entries often list Merck Sharp & Dohme LLC in connection with APREPITANT. Always verify the specific product and NDC with your pharmacist.

Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.