CHLORTHALIDONE

N/A

Manufactured by Casper Pharma LLC

23,419 FDA adverse event reports analyzed

Last updated: 2026-04-14

About CHLORTHALIDONE

CHLORTHALIDONE is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Casper Pharma LLC. The most commonly reported adverse reactions for CHLORTHALIDONE include FATIGUE, NAUSEA, DRUG INEFFECTIVE, DIARRHOEA, DIZZINESS. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for CHLORTHALIDONE.

Top Adverse Reactions

FATIGUE860 reports
NAUSEA704 reports
DRUG INEFFECTIVE701 reports
DIARRHOEA643 reports
DIZZINESS563 reports
PAIN541 reports
HEADACHE513 reports
DYSPNOEA509 reports
OFF LABEL USE499 reports
ACUTE KIDNEY INJURY471 reports
CHRONIC KIDNEY DISEASE455 reports
ARTHRALGIA432 reports
ASTHENIA419 reports
BLOOD PRESSURE INCREASED388 reports
HYPERTENSION387 reports
VOMITING377 reports
FALL361 reports
MALAISE343 reports
PRURITUS340 reports
RASH326 reports
WEIGHT DECREASED323 reports
RENAL FAILURE317 reports
COUGH312 reports
PERIPHERAL SWELLING287 reports
PNEUMONIA277 reports
DEATH275 reports
HYPONATRAEMIA275 reports
PAIN IN EXTREMITY268 reports
CONSTIPATION266 reports
BACK PAIN263 reports
CONDITION AGGRAVATED249 reports
PYREXIA249 reports
HYPOTENSION240 reports
PRODUCT DOSE OMISSION ISSUE235 reports
DECREASED APPETITE225 reports
INSOMNIA225 reports
WEIGHT INCREASED221 reports
DRUG INTERACTION220 reports
COVID 19218 reports
HYPOKALAEMIA213 reports
GAIT DISTURBANCE212 reports
DEHYDRATION211 reports
ANXIETY207 reports
FEELING ABNORMAL206 reports
OEDEMA PERIPHERAL206 reports
URINARY TRACT INFECTION202 reports
RENAL IMPAIRMENT196 reports
ABDOMINAL PAIN UPPER187 reports
ANAEMIA186 reports
NASOPHARYNGITIS178 reports
DEPRESSION176 reports
MUSCLE SPASMS168 reports
CHEST PAIN165 reports
SOMNOLENCE165 reports
BLOOD GLUCOSE INCREASED162 reports
MYALGIA159 reports
ABDOMINAL PAIN158 reports
BLOOD POTASSIUM DECREASED152 reports
SYNCOPE150 reports
PRODUCT USE IN UNAPPROVED INDICATION149 reports
PARAESTHESIA144 reports
JOINT SWELLING143 reports
MUSCULAR WEAKNESS142 reports
ATRIAL FIBRILLATION141 reports
ABDOMINAL DISCOMFORT140 reports
ASTHMA140 reports
GASTROOESOPHAGEAL REFLUX DISEASE137 reports
INJECTION SITE PAIN137 reports
TREMOR137 reports
ALOPECIA135 reports
DRUG HYPERSENSITIVITY135 reports
HYPOAESTHESIA134 reports
BLOOD CREATININE INCREASED132 reports
HYPERSENSITIVITY131 reports
CEREBROVASCULAR ACCIDENT128 reports
INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION128 reports
NEUROPATHY PERIPHERAL127 reports
URTICARIA126 reports
HOT FLUSH125 reports
WRONG TECHNIQUE IN PRODUCT USAGE PROCESS122 reports
CONFUSIONAL STATE121 reports
MUSCULOSKELETAL STIFFNESS118 reports
END STAGE RENAL DISEASE116 reports
PULMONARY EMBOLISM115 reports
MEMORY IMPAIRMENT114 reports
SINUSITIS114 reports
ERYTHEMA109 reports
SWELLING109 reports
CONTUSION108 reports
HYPERHIDROSIS105 reports
INTENTIONAL PRODUCT USE ISSUE104 reports
WHEEZING104 reports
ARTHRITIS103 reports
PRODUCT USE ISSUE103 reports
RENAL INJURY103 reports
BRONCHITIS102 reports
HAEMOGLOBIN DECREASED102 reports
NASAL CONGESTION101 reports
VISION BLURRED101 reports
INCORRECT DOSE ADMINISTERED98 reports

Report Outcomes

Out of 11,030 classified reports for CHLORTHALIDONE:

Serious 63.4%Non-Serious 36.6%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Female5,711 (56.0%)
Male4,472 (43.9%)
Unknown8 (0.1%)

Reports by Age

Age 76254 reports
Age 74233 reports
Age 63232 reports
Age 62228 reports
Age 69228 reports
Age 67224 reports
Age 66220 reports
Age 68219 reports
Age 71214 reports
Age 70212 reports
Age 72211 reports
Age 78200 reports
Age 61199 reports
Age 65199 reports
Age 73199 reports
Age 75190 reports
Age 64188 reports
Age 60185 reports
Age 57173 reports
Age 59169 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Frequently Asked Questions

How many FDA adverse event reports are associated with CHLORTHALIDONE?

This profile reflects 23,419 FDA FAERS reports that mention CHLORTHALIDONE. Reporting is voluntary and does not prove that the drug caused any listed event.

Which adverse reactions are most often listed for CHLORTHALIDONE?

Frequently reported terms in FAERS include FATIGUE, NAUSEA, DRUG INEFFECTIVE, DIARRHOEA, DIZZINESS, PAIN. Rankings reflect reporting volume in this dataset, not confirmed side effect rates in the general population.

Who manufactures CHLORTHALIDONE?

Labeling and FAERS entries often list Casper Pharma LLC in connection with CHLORTHALIDONE. Always verify the specific product and NDC with your pharmacist.

Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.