CRIZOTINIB

N/A

Manufactured by Pfizer Laboratories Div Pfizer Inc

22,895 FDA adverse event reports analyzed

Last updated: 2026-04-14

About CRIZOTINIB

CRIZOTINIB is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Pfizer Laboratories Div Pfizer Inc. The most commonly reported adverse reactions for CRIZOTINIB include DEATH, DISEASE PROGRESSION, NEOPLASM PROGRESSION, NAUSEA, DIARRHOEA. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for CRIZOTINIB.

Top Adverse Reactions

DEATH2,253 reports
DISEASE PROGRESSION1,214 reports
NEOPLASM PROGRESSION1,115 reports
NAUSEA1,107 reports
DIARRHOEA832 reports
VOMITING778 reports
FATIGUE550 reports
OFF LABEL USE461 reports
OEDEMA PERIPHERAL440 reports
CONSTIPATION433 reports
DYSPNOEA427 reports
LUNG NEOPLASM MALIGNANT415 reports
VISUAL IMPAIRMENT404 reports
DECREASED APPETITE373 reports
ASTHENIA335 reports
PNEUMONIA333 reports
DIZZINESS312 reports
MALAISE306 reports
PLEURAL EFFUSION305 reports
PERIPHERAL SWELLING290 reports
NON SMALL CELL LUNG CANCER280 reports
MALIGNANT NEOPLASM PROGRESSION279 reports
PYREXIA259 reports
COUGH247 reports
NEOPLASM MALIGNANT222 reports
DRUG INEFFECTIVE219 reports
RASH205 reports
DYSGEUSIA203 reports
OEDEMA199 reports
WEIGHT DECREASED191 reports
RENAL IMPAIRMENT184 reports
DYSPHAGIA181 reports
HEADACHE178 reports
PAIN176 reports
PULMONARY EMBOLISM170 reports
VISION BLURRED169 reports
ALANINE AMINOTRANSFERASE INCREASED168 reports
INTERSTITIAL LUNG DISEASE168 reports
ANAEMIA163 reports
DEHYDRATION161 reports
PRODUCT USE ISSUE155 reports
NEUTROPENIA153 reports
PRODUCT USE IN UNAPPROVED INDICATION151 reports
PNEUMONITIS150 reports
ASPARTATE AMINOTRANSFERASE INCREASED141 reports
HYPOTENSION141 reports
BLOOD CREATININE INCREASED136 reports
HEPATIC FUNCTION ABNORMAL135 reports
PHOTOPSIA135 reports
RENAL FAILURE134 reports
BRADYCARDIA132 reports
DRUG INTERACTION127 reports
GENERAL PHYSICAL HEALTH DETERIORATION127 reports
METASTASES TO CENTRAL NERVOUS SYSTEM124 reports
DRUG RESISTANCE121 reports
DYSPEPSIA120 reports
HEPATIC ENZYME INCREASED120 reports
ABDOMINAL PAIN115 reports
CARDIAC FAILURE115 reports
WEIGHT INCREASED115 reports
RESPIRATORY FAILURE114 reports
FALL112 reports
ELECTROCARDIOGRAM QT PROLONGED110 reports
DEEP VEIN THROMBOSIS109 reports
PERICARDIAL EFFUSION108 reports
ABDOMINAL DISCOMFORT102 reports
BACK PAIN101 reports
OESOPHAGITIS101 reports
ABDOMINAL PAIN UPPER100 reports
CONDITION AGGRAVATED97 reports
WHITE BLOOD CELL COUNT DECREASED97 reports
CHEST PAIN96 reports
TRANSAMINASES INCREASED94 reports
PAIN IN EXTREMITY93 reports
HAEMOGLOBIN DECREASED92 reports
THROMBOSIS92 reports
ACUTE KIDNEY INJURY91 reports
THROMBOCYTOPENIA91 reports
PULMONARY OEDEMA89 reports
SEPSIS88 reports
ARTHRALGIA86 reports
FEBRILE NEUTROPENIA86 reports
HEPATOTOXICITY85 reports
LIVER DISORDER85 reports
SEIZURE85 reports
HYPOAESTHESIA84 reports
HEART RATE DECREASED82 reports
NEUROPATHY PERIPHERAL80 reports
STOMATITIS79 reports
JOINT SWELLING77 reports
LUNG ADENOCARCINOMA77 reports
CONFUSIONAL STATE76 reports
VITREOUS FLOATERS75 reports
GAIT DISTURBANCE74 reports
GASTROOESOPHAGEAL REFLUX DISEASE74 reports
HYPONATRAEMIA73 reports
SWELLING73 reports
ABDOMINAL DISTENSION72 reports
INSOMNIA72 reports
PRURITUS71 reports

Report Outcomes

Out of 12,472 classified reports for CRIZOTINIB:

Serious 73.0%Non-Serious 27.0%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Female6,114 (54.4%)
Male5,025 (44.7%)
Unknown104 (0.9%)

Reports by Age

Age 70274 reports
Age 66257 reports
Age 63250 reports
Age 68243 reports
Age 60242 reports
Age 67235 reports
Age 69232 reports
Age 59230 reports
Age 71229 reports
Age 65225 reports
Age 56218 reports
Age 57217 reports
Age 62216 reports
Age 72213 reports
Age 74210 reports
Age 64204 reports
Age 58202 reports
Age 55197 reports
Age 73197 reports
Age 61189 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Frequently Asked Questions

How many FDA adverse event reports are associated with CRIZOTINIB?

This profile reflects 22,895 FDA FAERS reports that mention CRIZOTINIB. Reporting is voluntary and does not prove that the drug caused any listed event.

Which adverse reactions are most often listed for CRIZOTINIB?

Frequently reported terms in FAERS include DEATH, DISEASE PROGRESSION, NEOPLASM PROGRESSION, NAUSEA, DIARRHOEA, VOMITING. Rankings reflect reporting volume in this dataset, not confirmed side effect rates in the general population.

Who manufactures CRIZOTINIB?

Labeling and FAERS entries often list Pfizer Laboratories Div Pfizer Inc in connection with CRIZOTINIB. Always verify the specific product and NDC with your pharmacist.

Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.