PERPHENAZINE

N/A

Manufactured by Actavis Pharma, Inc.

7,483 FDA adverse event reports analyzed

Last updated: 2026-04-15

About PERPHENAZINE

PERPHENAZINE is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Actavis Pharma, Inc.. The most commonly reported adverse reactions for PERPHENAZINE include DRUG INEFFECTIVE, TOXICITY TO VARIOUS AGENTS, WEIGHT INCREASED, AKATHISIA, SUICIDE ATTEMPT. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for PERPHENAZINE.

Top Adverse Reactions

DRUG INEFFECTIVE357 reports
TOXICITY TO VARIOUS AGENTS274 reports
WEIGHT INCREASED222 reports
AKATHISIA184 reports
SUICIDE ATTEMPT180 reports
OFF LABEL USE172 reports
OBSESSIVE COMPULSIVE DISORDER163 reports
INCREASED APPETITE155 reports
EUPHORIC MOOD153 reports
PRODUCT USE IN UNAPPROVED INDICATION150 reports
ANTIPSYCHOTIC DRUG LEVEL BELOW THERAPEUTIC149 reports
DISINHIBITION148 reports
THERAPEUTIC PRODUCT EFFECT INCOMPLETE142 reports
THERAPEUTIC PRODUCT EFFECT VARIABLE140 reports
LEUKOPENIA139 reports
DRUG INTERACTION125 reports
HYPERTENSION117 reports
FATIGUE106 reports
NAUSEA97 reports
TARDIVE DYSKINESIA97 reports
FALL96 reports
PAIN96 reports
DYSPNOEA95 reports
OBESITY93 reports
COMPLETED SUICIDE88 reports
DYSKINESIA87 reports
CONSTIPATION85 reports
DIARRHOEA84 reports
DYSLIPIDAEMIA84 reports
DYSTONIA82 reports
LEUKAEMIA82 reports
HYPOTENSION81 reports
PARKINSONISM81 reports
OVERDOSE80 reports
TREMOR77 reports
PRESCRIBED OVERDOSE75 reports
INSOMNIA70 reports
SEDATION68 reports
IRRITABILITY66 reports
NEUROLEPTIC MALIGNANT SYNDROME62 reports
SOMNOLENCE61 reports
MOBILITY DECREASED59 reports
DRUG ABUSE57 reports
MYOCLONUS57 reports
DEPRESSED LEVEL OF CONSCIOUSNESS56 reports
DIZZINESS56 reports
BALANCE DISORDER55 reports
ANXIETY54 reports
ORTHOSTATIC HYPOTENSION54 reports
EXTRAPYRAMIDAL DISORDER53 reports
VOMITING51 reports
BLOOD CREATININE INCREASED50 reports
DEPRESSION50 reports
ASTHENIA49 reports
DRUG HYPERSENSITIVITY49 reports
COGNITIVE DISORDER47 reports
HEADACHE46 reports
RENAL IMPAIRMENT46 reports
SEDATION COMPLICATION46 reports
BLOOD CALCIUM DECREASED45 reports
AGITATION44 reports
ARTHRALGIA44 reports
INFECTION44 reports
OSTEOARTHRITIS44 reports
SLEEP DISORDER44 reports
DRUG INTOLERANCE43 reports
HYPONATRAEMIA43 reports
SEIZURE43 reports
CONDITION AGGRAVATED42 reports
CREATININE RENAL CLEARANCE DECREASED42 reports
DIABETES MELLITUS42 reports
GASTROINTESTINAL DISORDER42 reports
RENAL FUNCTION TEST ABNORMAL42 reports
TREATMENT FAILURE41 reports
DRY EYE40 reports
OSTEOPENIA40 reports
CYST39 reports
DEATH39 reports
SKIN LESION39 reports
BLOOD MAGNESIUM INCREASED38 reports
BLOOD POTASSIUM INCREASED38 reports
PLEURAL FIBROSIS38 reports
DEAFNESS NEUROSENSORY37 reports
DYSPHAGIA37 reports
EPIGASTRIC DISCOMFORT37 reports
MALAISE37 reports
PLEURAL THICKENING37 reports
PRESBYACUSIS37 reports
PYREXIA36 reports
CARDIAC ARREST35 reports
CREATININE RENAL CLEARANCE INCREASED35 reports
MOVEMENT DISORDER35 reports
APRAXIA34 reports
CONFUSIONAL STATE34 reports
FEELING ABNORMAL34 reports
PAIN IN EXTREMITY33 reports
PSYCHOTIC DISORDER33 reports
SCHIZOAFFECTIVE DISORDER33 reports
SUICIDAL IDEATION33 reports
HYPERSENSITIVITY32 reports

Report Outcomes

Out of 2,013 classified reports for PERPHENAZINE:

Serious 83.1%Non-Serious 16.9%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Female1,027 (55.6%)
Male810 (43.8%)
Unknown11 (0.6%)

Reports by Age

Age 5366 reports
Age 4061 reports
Age 7759 reports
Age 5746 reports
Age 3541 reports
Age 3237 reports
Age 4935 reports
Age 5633 reports
Age 4428 reports
Age 5028 reports
Age 6227 reports
Age 2926 reports
Age 4325 reports
Age 4525 reports
Age 5925 reports
Age 6525 reports
Age 8325 reports
Age 3324 reports
Age 3424 reports
Age 2823 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Frequently Asked Questions

How many FDA adverse event reports are associated with PERPHENAZINE?

This profile reflects 7,483 FDA FAERS reports that mention PERPHENAZINE. Reporting is voluntary and does not prove that the drug caused any listed event.

Which adverse reactions are most often listed for PERPHENAZINE?

Frequently reported terms in FAERS include DRUG INEFFECTIVE, TOXICITY TO VARIOUS AGENTS, WEIGHT INCREASED, AKATHISIA, SUICIDE ATTEMPT, OFF LABEL USE. Rankings reflect reporting volume in this dataset, not confirmed side effect rates in the general population.

Who manufactures PERPHENAZINE?

Labeling and FAERS entries often list Actavis Pharma, Inc. in connection with PERPHENAZINE. Always verify the specific product and NDC with your pharmacist.

Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.