SELINEXOR

N/A

Manufactured by Karyopharm Therapeutics Inc.

24,395 FDA adverse event reports analyzed

Last updated: 2026-04-14

About SELINEXOR

SELINEXOR is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Karyopharm Therapeutics Inc.. The most commonly reported adverse reactions for SELINEXOR include NAUSEA, FATIGUE, DECREASED APPETITE, DIARRHOEA, PLASMA CELL MYELOMA. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for SELINEXOR.

Top Adverse Reactions

NAUSEA2,493 reports
FATIGUE1,878 reports
DECREASED APPETITE1,337 reports
DIARRHOEA1,260 reports
PLASMA CELL MYELOMA1,143 reports
VOMITING898 reports
ASTHENIA834 reports
DEATH810 reports
THROMBOCYTOPENIA722 reports
PLATELET COUNT DECREASED647 reports
WEIGHT DECREASED628 reports
OFF LABEL USE472 reports
ANAEMIA454 reports
PNEUMONIA452 reports
DIZZINESS438 reports
CONSTIPATION414 reports
DRUG INEFFECTIVE402 reports
WHITE BLOOD CELL COUNT DECREASED296 reports
DYSPNOEA292 reports
DEHYDRATION275 reports
FALL273 reports
NEUTROPENIA239 reports
PYREXIA237 reports
CONFUSIONAL STATE230 reports
HEADACHE223 reports
PRODUCT DOSE OMISSION ISSUE220 reports
HYPONATRAEMIA211 reports
HAEMOGLOBIN DECREASED207 reports
INSOMNIA188 reports
SOMNOLENCE183 reports
ABDOMINAL DISCOMFORT173 reports
DISEASE PROGRESSION164 reports
MALAISE163 reports
COVID 19145 reports
TASTE DISORDER145 reports
PAIN141 reports
BACK PAIN136 reports
FULL BLOOD COUNT DECREASED136 reports
URINARY TRACT INFECTION134 reports
VISION BLURRED131 reports
ABDOMINAL PAIN UPPER125 reports
HYPOTENSION125 reports
SEPSIS124 reports
DYSGEUSIA123 reports
NEUROPATHY PERIPHERAL121 reports
ADVERSE EVENT111 reports
COUGH109 reports
INFECTION106 reports
LEUKOPENIA106 reports
FEBRILE NEUTROPENIA98 reports
EPISTAXIS96 reports
FEELING ABNORMAL93 reports
MUSCLE SPASMS93 reports
ACUTE KIDNEY INJURY92 reports
RED BLOOD CELL COUNT DECREASED90 reports
NEUTROPHIL COUNT DECREASED87 reports
AGEUSIA86 reports
PANCYTOPENIA86 reports
PERIPHERAL SWELLING84 reports
ABDOMINAL PAIN83 reports
DYSPEPSIA83 reports
ARTHRALGIA82 reports
NO ADVERSE EVENT81 reports
MYELOSUPPRESSION79 reports
GAIT DISTURBANCE78 reports
NASOPHARYNGITIS78 reports
BALANCE DISORDER77 reports
MEMORY IMPAIRMENT74 reports
LABORATORY TEST ABNORMAL73 reports
RENAL IMPAIRMENT72 reports
CYTOKINE RELEASE SYNDROME69 reports
MUSCULAR WEAKNESS69 reports
RASH68 reports
ALOPECIA66 reports
BLOOD GLUCOSE INCREASED66 reports
INTENTIONAL PRODUCT USE ISSUE66 reports
THERAPEUTIC PRODUCT EFFECT DECREASED66 reports
CHILLS64 reports
CYTOPENIA64 reports
LETHARGY64 reports
PRURITUS63 reports
CATARACT62 reports
THERAPY NON RESPONDER62 reports
PAIN IN EXTREMITY60 reports
SYNCOPE60 reports
INFLUENZA59 reports
VISUAL IMPAIRMENT59 reports
DRUG INTOLERANCE58 reports
ANXIETY56 reports
FLATULENCE54 reports
BLOOD CREATININE INCREASED53 reports
THERAPY PARTIAL RESPONDER53 reports
BLOOD SODIUM DECREASED52 reports
OEDEMA PERIPHERAL52 reports
DIFFUSE LARGE B CELL LYMPHOMA REFRACTORY51 reports
PULMONARY EMBOLISM49 reports
ABDOMINAL DISTENSION48 reports
HYPERSOMNIA48 reports
PLASMA CELL MYELOMA REFRACTORY48 reports
RETCHING47 reports

Report Outcomes

Out of 8,091 classified reports for SELINEXOR:

Serious 54.5%Non-Serious 45.5%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Male1,564 (54.6%)
Female1,299 (45.4%)
Unknown1 (0.0%)

Reports by Age

Age 67119 reports
Age 7095 reports
Age 6993 reports
Age 5792 reports
Age 7192 reports
Age 7291 reports
Age 6384 reports
Age 7483 reports
Age 6481 reports
Age 7380 reports
Age 6578 reports
Age 7677 reports
Age 6676 reports
Age 5875 reports
Age 6275 reports
Age 7875 reports
Age 6174 reports
Age 5972 reports
Age 7771 reports
Age 5669 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Frequently Asked Questions

How many FDA adverse event reports are associated with SELINEXOR?

This profile reflects 24,395 FDA FAERS reports that mention SELINEXOR. Reporting is voluntary and does not prove that the drug caused any listed event.

Which adverse reactions are most often listed for SELINEXOR?

Frequently reported terms in FAERS include NAUSEA, FATIGUE, DECREASED APPETITE, DIARRHOEA, PLASMA CELL MYELOMA, VOMITING. Rankings reflect reporting volume in this dataset, not confirmed side effect rates in the general population.

Who manufactures SELINEXOR?

Labeling and FAERS entries often list Karyopharm Therapeutics Inc. in connection with SELINEXOR. Always verify the specific product and NDC with your pharmacist.

Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.