SEVOFLURANE

N/A

Manufactured by AbbVie Inc.

11,848 FDA adverse event reports analyzed

Last updated: 2026-04-14

About SEVOFLURANE

SEVOFLURANE is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by AbbVie Inc.. The most commonly reported adverse reactions for SEVOFLURANE include HYPOTENSION, DRUG INTERACTION, CARDIAC ARREST, BRADYCARDIA, DRUG INEFFECTIVE. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for SEVOFLURANE.

Top Adverse Reactions

HYPOTENSION575 reports
DRUG INTERACTION475 reports
CARDIAC ARREST415 reports
BRADYCARDIA373 reports
DRUG INEFFECTIVE287 reports
HYPERTHERMIA MALIGNANT276 reports
ANAESTHETIC COMPLICATION NEUROLOGICAL275 reports
TACHYCARDIA254 reports
SEROTONIN SYNDROME252 reports
ANAPHYLACTIC SHOCK236 reports
ANAPHYLACTIC REACTION230 reports
FOETAL EXPOSURE DURING PREGNANCY219 reports
ACUTE KIDNEY INJURY214 reports
OXYGEN SATURATION DECREASED213 reports
OFF LABEL USE206 reports
BLOOD PRESSURE DECREASED191 reports
DELAYED RECOVERY FROM ANAESTHESIA181 reports
RHABDOMYOLYSIS176 reports
BRONCHOSPASM159 reports
HYPOXIA158 reports
VENTRICULAR FIBRILLATION150 reports
ANAESTHETIC COMPLICATION147 reports
VENTRICULAR TACHYCARDIA145 reports
PULMONARY OEDEMA142 reports
NAUSEA141 reports
DYSPNOEA140 reports
HYPERTENSION130 reports
RESPIRATORY FAILURE123 reports
METABOLIC ACIDOSIS119 reports
BLOOD CREATINE PHOSPHOKINASE INCREASED118 reports
ALANINE AMINOTRANSFERASE INCREASED116 reports
HEART RATE INCREASED108 reports
PYREXIA107 reports
RESPIRATORY DEPRESSION104 reports
HYPERKALAEMIA100 reports
POST PROCEDURAL COMPLICATION95 reports
VOMITING93 reports
HYPERTHERMIA92 reports
LOW BIRTH WEIGHT BABY92 reports
HAEMODYNAMIC INSTABILITY90 reports
SOMNOLENCE89 reports
UNWANTED AWARENESS DURING ANAESTHESIA89 reports
ERYTHEMA88 reports
APNOEA87 reports
PREMATURE BABY86 reports
TOXICITY TO VARIOUS AGENTS85 reports
ELECTROCARDIOGRAM QT PROLONGED84 reports
RENAL FAILURE84 reports
BLOOD POTASSIUM INCREASED82 reports
CARDIO RESPIRATORY ARREST81 reports
PULMONARY ALVEOLAR HAEMORRHAGE81 reports
STRESS CARDIOMYOPATHY81 reports
DYSTONIA80 reports
PAIN80 reports
TORSADE DE POINTES79 reports
DIABETES INSIPIDUS78 reports
BLOOD LACTATE DEHYDROGENASE INCREASED77 reports
MATERNAL EXPOSURE DURING PREGNANCY76 reports
AGITATION75 reports
OVERDOSE75 reports
CIRCULATORY COLLAPSE74 reports
TROPONIN INCREASED71 reports
PRODUCT USE IN UNAPPROVED INDICATION70 reports
RENAL FAILURE ACUTE70 reports
URTICARIA70 reports
EXPOSURE DURING PREGNANCY69 reports
COMA68 reports
CONDITION AGGRAVATED68 reports
HYPERCAPNIA67 reports
LARYNGOSPASM67 reports
PROCEDURAL COMPLICATION67 reports
TOXIC ENCEPHALOPATHY67 reports
MYOGLOBIN URINE PRESENT66 reports
BLOOD PRESSURE INCREASED65 reports
TACHYPNOEA65 reports
AMYLASE INCREASED64 reports
CONVULSION64 reports
RESPIRATORY ACIDOSIS64 reports
HEART RATE DECREASED62 reports
NEUROMUSCULAR BLOCK PROLONGED62 reports
CARDIAC FAILURE61 reports
RESPIRATORY ARREST61 reports
CYANOSIS60 reports
DEATH60 reports
DYSKINESIA60 reports
MUSCLE RIGIDITY60 reports
PNEUMONIA60 reports
RASH60 reports
DEPRESSED LEVEL OF CONSCIOUSNESS59 reports
HAEMORRHAGE59 reports
SINUS TACHYCARDIA59 reports
VENTRICULAR EXTRASYSTOLES58 reports
CONFUSIONAL STATE57 reports
RENAL IMPAIRMENT56 reports
ANXIETY55 reports
SHOCK55 reports
HYPERSENSITIVITY54 reports
PRODUCT USE ISSUE54 reports
SEIZURE54 reports
LOSS OF CONSCIOUSNESS52 reports

Report Outcomes

Out of 7,719 classified reports for SEVOFLURANE:

Serious 94.5%Non-Serious 5.5%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Female3,016 (49.0%)
Male2,980 (48.4%)
Unknown156 (2.5%)

Reports by Age

Age 49133 reports
Age 3130 reports
Age 71101 reports
Age 599 reports
Age 898 reports
Age 290 reports
Age 7090 reports
Age 1589 reports
Age 1689 reports
Age 6788 reports
Age 486 reports
Age 5786 reports
Age 1484 reports
Age 683 reports
Age 2083 reports
Age 5583 reports
Age 1382 reports
Age 5881 reports
Age 780 reports
Age 7476 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Frequently Asked Questions

How many FDA adverse event reports are associated with SEVOFLURANE?

This profile reflects 11,848 FDA FAERS reports that mention SEVOFLURANE. Reporting is voluntary and does not prove that the drug caused any listed event.

Which adverse reactions are most often listed for SEVOFLURANE?

Frequently reported terms in FAERS include HYPOTENSION, DRUG INTERACTION, CARDIAC ARREST, BRADYCARDIA, DRUG INEFFECTIVE, HYPERTHERMIA MALIGNANT. Rankings reflect reporting volume in this dataset, not confirmed side effect rates in the general population.

Who manufactures SEVOFLURANE?

Labeling and FAERS entries often list AbbVie Inc. in connection with SEVOFLURANE. Always verify the specific product and NDC with your pharmacist.

Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.