CITALOPRAM HYDROBROMIDE

85/100 · Critical

Manufactured by Aurobindo Pharma Limited

Citalopram Hydrobromide Adverse Events: High Seriousness and Diverse Reactions

209,370 FDA adverse event reports analyzed

Last updated: 2026-05-12

About CITALOPRAM HYDROBROMIDE

CITALOPRAM HYDROBROMIDE is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Aurobindo Pharma Limited. Based on analysis of 209,370 FDA adverse event reports, CITALOPRAM HYDROBROMIDE has a safety score of 85 out of 100. This score indicates a relatively favorable safety profile, with fewer or less severe adverse events compared to many other tracked medications. The most commonly reported adverse reactions for CITALOPRAM HYDROBROMIDE include FATIGUE, NAUSEA, DRUG INEFFECTIVE, HEADACHE, TOXICITY TO VARIOUS AGENTS. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for CITALOPRAM HYDROBROMIDE.

AI Safety Analysis

Citalopram Hydrobromide has a safety concern score of 85 out of 100, placing it in the high concern category based on analysis of FDA adverse event data. The FDA has received approximately 209,370 adverse event reports for this medication, which is primarily manufactured by Aurobindo Pharma Limited.

The most commonly reported adverse events include Fatigue, Nausea, Drug Ineffective. Of classified reports, 82.2% were designated as serious by the FDA, meaning they involved hospitalization, disability, or other significant medical outcomes. High incidence of serious adverse events, particularly suicide and overdose.

Diverse range of reactions, including neurological, gastrointestinal, and cardiovascular issues. Significant reports of depression and anxiety, indicating potential mental health risks.

Patients taking Citalopram Hydrobromide should monitor for the commonly reported side effects and contact their healthcare provider if they experience any unusual symptoms. Citalopram Hydrobromide can interact with other drugs, leading to toxicity and increased risk of adverse events. Overdose is a significant concern, and patients should be monitored closely. This analysis is based on voluntary FDA adverse event reports and should not replace professional medical advice.

Safety Score: 85/100

Citalopram Hydrobromide received a safety concern score of 85/100 (high concern). This is based on a 82.2% serious event ratio across 104,249 classified reports. The score accounts for 209,370 total adverse event reports and 100 distinct reaction types. This high score reflects a significant proportion of serious adverse events in the reporting data.

Top Adverse Reactions

FATIGUE6,825 reports
NAUSEA5,889 reports
DRUG INEFFECTIVE5,398 reports
HEADACHE5,017 reports
TOXICITY TO VARIOUS AGENTS4,970 reports
DIARRHOEA4,710 reports
FALL4,360 reports
DIZZINESS4,323 reports
PAIN4,306 reports
OFF LABEL USE4,199 reports
COMPLETED SUICIDE4,147 reports
DYSPNOEA4,069 reports
DRUG INTERACTION4,003 reports
ANXIETY3,864 reports
VOMITING3,682 reports
DEPRESSION3,522 reports
MALAISE3,353 reports
DEATH3,095 reports
ASTHENIA3,063 reports
ARTHRALGIA2,972 reports
DRUG ABUSE2,698 reports
OVERDOSE2,648 reports
CONFUSIONAL STATE2,639 reports
INSOMNIA2,528 reports
PYREXIA2,506 reports
SOMNOLENCE2,498 reports
RASH2,442 reports
CONDITION AGGRAVATED2,422 reports
WEIGHT DECREASED2,343 reports
PNEUMONIA2,313 reports
TREMOR2,304 reports
PAIN IN EXTREMITY2,216 reports
CONSTIPATION2,193 reports
BACK PAIN2,157 reports
HYPERHIDROSIS2,152 reports
PRURITUS2,122 reports
COUGH2,104 reports
WEIGHT INCREASED2,072 reports
HYPERTENSION1,999 reports
SUICIDAL IDEATION1,967 reports
ABDOMINAL PAIN1,946 reports
HYPOTENSION1,946 reports
FEELING ABNORMAL1,842 reports
DECREASED APPETITE1,810 reports
ACUTE KIDNEY INJURY1,717 reports
GAIT DISTURBANCE1,679 reports
SUICIDE ATTEMPT1,644 reports
INTENTIONAL OVERDOSE1,619 reports
URINARY TRACT INFECTION1,604 reports
ELECTROCARDIOGRAM QT PROLONGED1,603 reports
HYPONATRAEMIA1,597 reports
CHEST PAIN1,515 reports
LOSS OF CONSCIOUSNESS1,512 reports
AGITATION1,502 reports
ANAEMIA1,489 reports
ABDOMINAL PAIN UPPER1,487 reports
MEMORY IMPAIRMENT1,455 reports
HYPERSENSITIVITY1,413 reports
RENAL FAILURE1,390 reports
SEROTONIN SYNDROME1,386 reports
FOETAL EXPOSURE DURING PREGNANCY1,366 reports
CHRONIC KIDNEY DISEASE1,361 reports
CARDIAC ARREST1,346 reports
ASTHMA1,332 reports
PARAESTHESIA1,327 reports
ERYTHEMA1,325 reports
NASOPHARYNGITIS1,295 reports
RHEUMATOID ARTHRITIS1,261 reports
SYNCOPE1,257 reports
DRUG HYPERSENSITIVITY1,250 reports
HYPOAESTHESIA1,240 reports
ABDOMINAL DISCOMFORT1,227 reports
MUSCLE SPASMS1,202 reports
JOINT SWELLING1,191 reports
BLOOD PRESSURE INCREASED1,189 reports
GENERAL PHYSICAL HEALTH DETERIORATION1,188 reports
MYALGIA1,169 reports
TACHYCARDIA1,158 reports
PERIPHERAL SWELLING1,154 reports
PRODUCT USE IN UNAPPROVED INDICATION1,151 reports
DEHYDRATION1,144 reports
PALPITATIONS1,109 reports
HALLUCINATION1,091 reports
ALOPECIA1,077 reports
BALANCE DISORDER1,073 reports
ACCIDENTAL OVERDOSE1,041 reports
COVID 191,037 reports
CARDIO RESPIRATORY ARREST1,016 reports
PRODUCT USE ISSUE1,005 reports
MUSCULAR WEAKNESS1,004 reports
SEIZURE999 reports
THROMBOCYTOPENIA974 reports
INTENTIONAL PRODUCT MISUSE970 reports
DISTURBANCE IN ATTENTION968 reports
CONTUSION954 reports
INFECTION949 reports
PSORIASIS946 reports
OEDEMA PERIPHERAL941 reports
PRODUCT DOSE OMISSION ISSUE924 reports
URTICARIA913 reports

Key Safety Signals

  • High number of serious adverse events (85,672 out of 104,249, 82.2%)
  • Multiple reports of suicidal ideation and completed suicides
  • Frequent occurrence of drug interactions and overdose incidents

Patient Demographics

Adverse event reports by sex: Female: 62,761, Male: 32,796, Unknown: 293. The most frequently reported age groups are age 58 (1,885 reports), age 57 (1,559 reports), age 60 (1,514 reports). These demographics reflect reporting patterns and may not represent the full patient population.

Report Outcomes

Out of 104,249 classified reports for CITALOPRAM HYDROBROMIDE:

  • Serious: 85,672 reports (82.2%) — includes hospitalization, disability, life-threatening events, or death
  • Non-Serious: 18,577 reports (17.8%)
Serious 82.2%Non-Serious 17.8%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Female62,761 (65.5%)
Male32,796 (34.2%)
Unknown293 (0.3%)

Reports by Age

Age 581,885 reports
Age 571,559 reports
Age 601,514 reports
Age 551,513 reports
Age 651,493 reports
Age 591,488 reports
Age 541,487 reports
Age 531,478 reports
Age 611,451 reports
Age 641,412 reports
Age 521,378 reports
Age 561,377 reports
Age 621,350 reports
Age 711,349 reports
Age 691,343 reports
Age 501,341 reports
Age 671,341 reports
Age 661,340 reports
Age 511,321 reports
Age 631,268 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Drug Interactions & Warnings

Citalopram Hydrobromide can interact with other drugs, leading to toxicity and increased risk of adverse events. Overdose is a significant concern, and patients should be monitored closely.

What You Should Know

If you are taking Citalopram Hydrobromide, here are important things to know. The most commonly reported side effects include fatigue, nausea, drug ineffective, headache, toxicity to various agents. While many of these may be mild and temporary, you should contact your healthcare provider if any symptoms are severe or persistent. Patients should strictly follow prescribed dosages and avoid self-adjustment. Inform healthcare providers about any existing conditions or medications to avoid potential interactions. If you experience a serious adverse reaction, seek emergency medical attention immediately or call 911. You can report side effects to the FDA's MedWatch program at 1-800-FDA-1088.

Regulatory Context

The FDA continues to monitor the safety of Citalopram Hydrobromide, particularly for serious adverse events like suicide and overdose. Regular medical check-ups are recommended for patients on this medication.

Frequently Asked Questions

How many adverse event reports has the FDA received for Citalopram Hydrobromide?

The FDA has received approximately 209,370 adverse event reports associated with Citalopram Hydrobromide. These reports come from healthcare professionals, consumers, and manufacturers through the FDA Adverse Event Reporting System (FAERS). Note that the number of reports does not directly indicate the frequency of side effects, as adverse events are voluntarily reported and may be underrepresented.

What are the most commonly reported side effects of Citalopram Hydrobromide?

The most frequently reported adverse events for Citalopram Hydrobromide include Fatigue, Nausea, Drug Ineffective, Headache, Toxicity To Various Agents. By volume, the top reported reactions are: Fatigue (6,825 reports), Nausea (5,889 reports), Drug Ineffective (5,398 reports). These figures reflect FDA adverse event reports and may not represent the true incidence rate of these side effects in all patients taking Citalopram Hydrobromide.

What percentage of Citalopram Hydrobromide adverse event reports are serious?

Out of 104,249 classified reports, 85,672 (82.2%) were classified as serious and 18,577 as non-serious. The FDA classifies an event as "serious" if it results in death, hospitalization, disability, or other medically significant outcomes. A higher serious-event ratio warrants closer attention but does not necessarily mean the drug is unsafe.

Who reports adverse events for Citalopram Hydrobromide (by sex)?

Adverse event reports for Citalopram Hydrobromide break down by patient sex as follows: Female: 62,761, Male: 32,796, Unknown: 293. This distribution reflects reporting patterns rather than actual risk differences between groups. Reporting rates can be influenced by prescribing patterns, disease demographics, and reporting behavior.

What age groups report the most side effects for Citalopram Hydrobromide?

The most frequently reported age groups for Citalopram Hydrobromide adverse events are: age 58: 1,885 reports, age 57: 1,559 reports, age 60: 1,514 reports, age 55: 1,513 reports, age 65: 1,493 reports. Age-related reporting patterns can reflect both the demographics of the patient population and potential age-related susceptibility to certain side effects.

Who manufactures Citalopram Hydrobromide?

The primary manufacturer associated with Citalopram Hydrobromide adverse event reports is Aurobindo Pharma Limited. Multiple manufacturers may produce generic versions of this drug. The manufacturer listed reflects the most frequently reported brand in FDA adverse event data.

What other side effects have been reported for Citalopram Hydrobromide?

Beyond the most common reactions, other reported adverse events for Citalopram Hydrobromide include: Diarrhoea, Fall, Dizziness, Pain, Off Label Use. Less common side effects can still be clinically significant. Patients should report any unusual symptoms to their healthcare provider.

How do I report a side effect from Citalopram Hydrobromide?

You can report adverse events from Citalopram Hydrobromide to the FDA through their MedWatch program at www.fda.gov/medwatch, by calling 1-800-FDA-1088, or by completing Form FDA 3500. Healthcare professionals, consumers, and manufacturers can all submit reports. Reporting helps the FDA monitor drug safety after approval.

What is Citalopram Hydrobromide's safety score and what does it mean?

Citalopram Hydrobromide has a safety concern score of 85 out of 100 (high concern). This score is calculated from the ratio of serious to non-serious adverse events, the diversity of reported reactions, and the overall volume of reports relative to usage. High incidence of serious adverse events, particularly suicide and overdose.

What are the key safety signals for Citalopram Hydrobromide?

Key safety signals identified in Citalopram Hydrobromide's adverse event data include: High number of serious adverse events (85,672 out of 104,249, 82.2%). Multiple reports of suicidal ideation and completed suicides. Frequent occurrence of drug interactions and overdose incidents. These signals are derived from patterns in FDA reports and should be discussed with a healthcare provider for personalized assessment.

Does Citalopram Hydrobromide interact with other drugs?

Citalopram Hydrobromide can interact with other drugs, leading to toxicity and increased risk of adverse events. Overdose is a significant concern, and patients should be monitored closely. Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking before starting Citalopram Hydrobromide.

What should patients know before taking Citalopram Hydrobromide?

Patients should strictly follow prescribed dosages and avoid self-adjustment. Inform healthcare providers about any existing conditions or medications to avoid potential interactions.

Are Citalopram Hydrobromide side effects well-documented?

Citalopram Hydrobromide has 209,370 adverse event reports on file with the FDA. Diverse range of reactions, including neurological, gastrointestinal, and cardiovascular issues. The volume of reports for Citalopram Hydrobromide reflects both the drug's usage level and the vigilance of the reporting community.

What is the FDA's position on Citalopram Hydrobromide?

The FDA continues to monitor the safety of Citalopram Hydrobromide, particularly for serious adverse events like suicide and overdose. Regular medical check-ups are recommended for patients on this medication. For the most current regulatory information, check the FDA's drug labeling database or consult your pharmacist.

Related Drugs

Drugs related to CITALOPRAM HYDROBROMIDE based on therapeutic use, drug class, or shared indications:

EscitalopramSertralineFluoxetineParoxetineFluvoxamine
Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.