65/100 · Elevated
Manufactured by Boiron
Moderate Safety Concerns with Magnesium Chloride Use
4,533 FDA adverse event reports analyzed
Last updated: 2026-05-12
MAGNESIUM CHLORIDE is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Boiron. Based on analysis of 4,533 FDA adverse event reports, MAGNESIUM CHLORIDE has a safety score of 65 out of 100. This moderate score indicates a notable volume of adverse event reports that patients and providers should be aware of. The most commonly reported adverse reactions for MAGNESIUM CHLORIDE include FATIGUE, NAUSEA, DIARRHOEA, OFF LABEL USE, ASTHENIA. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for MAGNESIUM CHLORIDE.
Magnesium Chloride has a safety concern score of 65 out of 100, placing it in the elevated concern category based on analysis of FDA adverse event data. The FDA has received approximately 4,533 adverse event reports for this medication, which is primarily manufactured by Boiron.
The most commonly reported adverse events include Fatigue, Nausea, Diarrhoea. Of classified reports, 75.6% were designated as serious by the FDA, meaning they involved hospitalization, disability, or other significant medical outcomes. Fatigue, nausea, and diarrhea are the most common adverse reactions reported.
Serious reactions, including death and pneumonia, are reported but less frequent. Off-label use is a significant concern, with 117 reports of unapproved indications. Drug ineffectiveness and product use issues are also notable.
Patients taking Magnesium Chloride should monitor for the commonly reported side effects and contact their healthcare provider if they experience any unusual symptoms. Magnesium Chloride has been associated with drug ineffectiveness and product use issues, suggesting potential misuse or incorrect dosage. This analysis is based on voluntary FDA adverse event reports and should not replace professional medical advice.
Magnesium Chloride received a safety concern score of 65/100 (elevated concern). This is based on a 75.6% serious event ratio across 1,608 classified reports. The score accounts for 4,533 total adverse event reports and 100 distinct reaction types. This elevated score indicates a notable proportion of serious adverse events and warrants careful monitoring.
Adverse event reports by sex: Female: 895, Male: 588, Unknown: 1. The most frequently reported age groups are age 43 (44 reports), age 67 (38 reports), age 75 (35 reports). These demographics reflect reporting patterns and may not represent the full patient population.
Out of 1,608 classified reports for MAGNESIUM CHLORIDE:
The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.
Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.
Magnesium Chloride has been associated with drug ineffectiveness and product use issues, suggesting potential misuse or incorrect dosage.
If you are taking Magnesium Chloride, here are important things to know. The most commonly reported side effects include fatigue, nausea, diarrhoea, off label use, asthenia. While many of these may be mild and temporary, you should contact your healthcare provider if any symptoms are severe or persistent. Always follow the prescribed dosage and use as directed by a healthcare provider. Report any adverse reactions to the FDA's MedWatch program for further evaluation. If you experience a serious adverse reaction, seek emergency medical attention immediately or call 911. You can report side effects to the FDA's MedWatch program at 1-800-FDA-1088.
The FDA continues to monitor the safety profile of Magnesium Chloride, with serious adverse events reported but not at a high frequency.
The FDA has received approximately 4,533 adverse event reports associated with Magnesium Chloride. These reports come from healthcare professionals, consumers, and manufacturers through the FDA Adverse Event Reporting System (FAERS). Note that the number of reports does not directly indicate the frequency of side effects, as adverse events are voluntarily reported and may be underrepresented.
The most frequently reported adverse events for Magnesium Chloride include Fatigue, Nausea, Diarrhoea, Off Label Use, Asthenia. By volume, the top reported reactions are: Fatigue (136 reports), Nausea (120 reports), Diarrhoea (118 reports). These figures reflect FDA adverse event reports and may not represent the true incidence rate of these side effects in all patients taking Magnesium Chloride.
Out of 1,608 classified reports, 1,216 (75.6%) were classified as serious and 392 as non-serious. The FDA classifies an event as "serious" if it results in death, hospitalization, disability, or other medically significant outcomes. A higher serious-event ratio warrants closer attention but does not necessarily mean the drug is unsafe.
Adverse event reports for Magnesium Chloride break down by patient sex as follows: Female: 895, Male: 588, Unknown: 1. This distribution reflects reporting patterns rather than actual risk differences between groups. Reporting rates can be influenced by prescribing patterns, disease demographics, and reporting behavior.
The most frequently reported age groups for Magnesium Chloride adverse events are: age 43: 44 reports, age 67: 38 reports, age 75: 35 reports, age 68: 33 reports, age 76: 32 reports. Age-related reporting patterns can reflect both the demographics of the patient population and potential age-related susceptibility to certain side effects.
The primary manufacturer associated with Magnesium Chloride adverse event reports is Boiron. Multiple manufacturers may produce generic versions of this drug. The manufacturer listed reflects the most frequently reported brand in FDA adverse event data.
Beyond the most common reactions, other reported adverse events for Magnesium Chloride include: Pain, Drug Ineffective, Dizziness, Dyspnoea, Headache. Less common side effects can still be clinically significant. Patients should report any unusual symptoms to their healthcare provider.
You can report adverse events from Magnesium Chloride to the FDA through their MedWatch program at www.fda.gov/medwatch, by calling 1-800-FDA-1088, or by completing Form FDA 3500. Healthcare professionals, consumers, and manufacturers can all submit reports. Reporting helps the FDA monitor drug safety after approval.
Magnesium Chloride has a safety concern score of 65 out of 100 (elevated concern). This score is calculated from the ratio of serious to non-serious adverse events, the diversity of reported reactions, and the overall volume of reports relative to usage. Fatigue, nausea, and diarrhea are the most common adverse reactions reported.
Key safety signals identified in Magnesium Chloride's adverse event data include: Death and pneumonia are serious adverse events reported.. Off-label use is a key safety signal, indicating potential misuse.. Multiple gastrointestinal issues (fatigue, nausea, diarrhea) are frequently reported.. These signals are derived from patterns in FDA reports and should be discussed with a healthcare provider for personalized assessment.
Magnesium Chloride has been associated with drug ineffectiveness and product use issues, suggesting potential misuse or incorrect dosage. Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking before starting Magnesium Chloride.
Always follow the prescribed dosage and use as directed by a healthcare provider. Report any adverse reactions to the FDA's MedWatch program for further evaluation.
Magnesium Chloride has 4,533 adverse event reports on file with the FDA. Serious reactions, including death and pneumonia, are reported but less frequent. The volume of reports for Magnesium Chloride reflects both the drug's usage level and the vigilance of the reporting community.
The FDA continues to monitor the safety profile of Magnesium Chloride, with serious adverse events reported but not at a high frequency. For the most current regulatory information, check the FDA's drug labeling database or consult your pharmacist.
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