TERIPARATIDE

55/100 · Moderate

Manufactured by Eli Lilly and Company

Teriparatide Adverse Events: Common Mild Reactions with Some Serious Concerns

227,333 FDA adverse event reports analyzed

Last updated: 2026-05-12

About TERIPARATIDE

TERIPARATIDE is a medication tracked in the FDA Adverse Event Reporting System (FAERS), manufactured by Eli Lilly and Company. Based on analysis of 227,333 FDA adverse event reports, TERIPARATIDE has a safety score of 55 out of 100. This moderate score indicates a notable volume of adverse event reports that patients and providers should be aware of. The most commonly reported adverse reactions for TERIPARATIDE include NAUSEA, ARTHRALGIA, PAIN IN EXTREMITY, DIZZINESS, FALL. This page provides a comprehensive breakdown of reported side effects, safety signals, patient demographics, and AI-powered safety analysis for TERIPARATIDE.

AI Safety Analysis

Teriparatide has a safety concern score of 55 out of 100, placing it in the elevated concern category based on analysis of FDA adverse event data. The FDA has received approximately 227,333 adverse event reports for this medication, which is primarily manufactured by Eli Lilly And Company.

The most commonly reported adverse events include Nausea, Arthralgia, Pain In Extremity. Of classified reports, 37.0% were designated as serious by the FDA, meaning they involved hospitalization, disability, or other significant medical outcomes. The most common reactions are nausea, arthralgia, and pain in extremity, indicating a high incidence of musculoskeletal discomfort.

Serious adverse events, such as falls and death, are reported but at a lower rate compared to non-serious events. Injection site reactions are frequent, highlighting the importance of proper administration.

Patients taking Teriparatide should monitor for the commonly reported side effects and contact their healthcare provider if they experience any unusual symptoms. Teriparatide can cause injection site reactions, and patients should be monitored for signs of hypercalcemia and other serious adverse events. This analysis is based on voluntary FDA adverse event reports and should not replace professional medical advice.

Safety Score: 55/100

Teriparatide received a safety concern score of 55/100 (elevated concern). This is based on a 37.0% serious event ratio across 111,255 classified reports. The score accounts for 227,333 total adverse event reports and 100 distinct reaction types. This elevated score indicates a notable proportion of serious adverse events and warrants careful monitoring.

Top Adverse Reactions

NAUSEA8,955 reports
ARTHRALGIA8,661 reports
PAIN IN EXTREMITY8,342 reports
DIZZINESS8,265 reports
FALL7,876 reports
PAIN7,522 reports
FATIGUE7,162 reports
BACK PAIN5,905 reports
MUSCLE SPASMS5,730 reports
MALAISE5,660 reports
HEADACHE5,461 reports
ASTHENIA5,429 reports
INJECTION SITE ERYTHEMA5,042 reports
INJECTION SITE PAIN4,808 reports
INJECTION SITE BRUISING4,761 reports
INJECTION SITE HAEMORRHAGE4,493 reports
FEELING ABNORMAL4,304 reports
BONE PAIN4,111 reports
DRUG DOSE OMISSION3,279 reports
DEATH2,960 reports
GAIT DISTURBANCE2,800 reports
DIARRHOEA2,622 reports
DYSPNOEA2,558 reports
MYALGIA2,545 reports
CONSTIPATION2,536 reports
VOMITING2,411 reports
CONTUSION2,396 reports
WEIGHT DECREASED2,222 reports
MUSCULAR WEAKNESS2,140 reports
PNEUMONIA2,123 reports
HEART RATE INCREASED2,043 reports
BLOOD CALCIUM INCREASED2,033 reports
ANXIETY2,022 reports
INSOMNIA2,020 reports
ABDOMINAL PAIN UPPER1,808 reports
PRURITUS1,740 reports
PHARMACEUTICAL PRODUCT COMPLAINT1,739 reports
HOSPITALISATION1,714 reports
BONE DENSITY DECREASED1,711 reports
WEIGHT INCREASED1,698 reports
ABDOMINAL DISCOMFORT1,659 reports
DECREASED APPETITE1,592 reports
NASOPHARYNGITIS1,582 reports
INTENTIONAL PRODUCT MISUSE1,527 reports
PALPITATIONS1,517 reports
RASH1,480 reports
COUGH1,475 reports
ARTHRITIS1,464 reports
OFF LABEL USE1,456 reports
HIP FRACTURE1,446 reports
TREMOR1,412 reports
DRUG INEFFECTIVE1,347 reports
MEDICATION ERROR1,345 reports
SPINAL FRACTURE1,270 reports
CHEST PAIN1,263 reports
NERVOUSNESS1,261 reports
MUSCULOSKELETAL PAIN1,244 reports
BALANCE DISORDER1,239 reports
MEMORY IMPAIRMENT1,228 reports
BLOOD PRESSURE INCREASED1,226 reports
PYREXIA1,201 reports
ALOPECIA1,163 reports
SOMNOLENCE1,154 reports
URINARY TRACT INFECTION1,154 reports
PERIPHERAL SWELLING1,136 reports
NECK PAIN1,130 reports
ERYTHEMA1,087 reports
OEDEMA PERIPHERAL1,082 reports
JOINT SWELLING1,057 reports
DEPRESSION1,056 reports
HYPERTENSION1,049 reports
FEMUR FRACTURE1,016 reports
PARAESTHESIA1,003 reports
HYPOAESTHESIA983 reports
CEREBROVASCULAR ACCIDENT975 reports
INFLUENZA960 reports
MUSCULOSKELETAL STIFFNESS959 reports
FRACTURE955 reports
ABDOMINAL DISTENSION954 reports
ABDOMINAL PAIN948 reports
MOBILITY DECREASED942 reports
LOSS OF CONSCIOUSNESS918 reports
NEPHROLITHIASIS898 reports
VISUAL IMPAIRMENT876 reports
LIMB DISCOMFORT875 reports
ANAEMIA860 reports
UPPER LIMB FRACTURE860 reports
CONFUSIONAL STATE850 reports
BONE DISORDER846 reports
HYPERSENSITIVITY824 reports
HYPERHIDROSIS819 reports
BRONCHITIS797 reports
DISCOMFORT795 reports
FEAR795 reports
INCORRECT DOSE ADMINISTERED793 reports
MUSCULOSKELETAL DISCOMFORT791 reports
BLOOD PRESSURE DECREASED787 reports
DYSPEPSIA786 reports
ARTHROPATHY783 reports
DEHYDRATION776 reports

Key Safety Signals

  • Falls and fractures are reported, which could be related to the drug's mechanism of action on bone density.
  • Increased blood calcium levels are noted, suggesting a risk of hypercalcemia.
  • Death reports are present, though not frequent, indicating a need for careful monitoring.

Patient Demographics

Adverse event reports by sex: Female: 99,358, Male: 10,240, Unknown: 40. The most frequently reported age groups are age 75 (2,734 reports), age 76 (2,047 reports), age 77 (2,033 reports). These demographics reflect reporting patterns and may not represent the full patient population.

Report Outcomes

Out of 111,255 classified reports for TERIPARATIDE:

  • Serious: 41,183 reports (37.0%) — includes hospitalization, disability, life-threatening events, or death
  • Non-Serious: 70,072 reports (63.0%)
Serious 37.0%Non-Serious 63.0%

The FDA classifies an adverse event as “serious” if it results in death, hospitalization, disability, congenital anomaly, or requires intervention to prevent permanent damage.

Demographics Breakdown

Reports by Sex

Female99,358 (90.6%)
Male10,240 (9.3%)
Unknown40 (0.0%)

Reports by Age

Age 752,734 reports
Age 762,047 reports
Age 772,033 reports
Age 781,990 reports
Age 791,964 reports
Age 801,937 reports
Age 741,931 reports
Age 651,929 reports
Age 721,924 reports
Age 701,883 reports
Age 731,858 reports
Age 711,809 reports
Age 691,757 reports
Age 681,727 reports
Age 811,682 reports
Age 821,677 reports
Age 661,632 reports
Age 671,609 reports
Age 831,537 reports
Age 851,485 reports

Demographics reflect voluntary FDA adverse event reporting patterns and may not represent the full patient population.

Drug Interactions & Warnings

Teriparatide can cause injection site reactions, and patients should be monitored for signs of hypercalcemia and other serious adverse events.

What You Should Know

If you are taking Teriparatide, here are important things to know. The most commonly reported side effects include nausea, arthralgia, pain in extremity, dizziness, fall. While many of these may be mild and temporary, you should contact your healthcare provider if any symptoms are severe or persistent. Patients should report any unusual symptoms to their healthcare provider immediately. Proper administration techniques should be followed to minimize injection site reactions. If you experience a serious adverse reaction, seek emergency medical attention immediately or call 911. You can report side effects to the FDA's MedWatch program at 1-800-FDA-1088.

Regulatory Context

The FDA continues to monitor teriparatide for safety, and updates will be provided as necessary based on ongoing reviews.

Frequently Asked Questions

How many adverse event reports has the FDA received for Teriparatide?

The FDA has received approximately 227,333 adverse event reports associated with Teriparatide. These reports come from healthcare professionals, consumers, and manufacturers through the FDA Adverse Event Reporting System (FAERS). Note that the number of reports does not directly indicate the frequency of side effects, as adverse events are voluntarily reported and may be underrepresented.

What are the most commonly reported side effects of Teriparatide?

The most frequently reported adverse events for Teriparatide include Nausea, Arthralgia, Pain In Extremity, Dizziness, Fall. By volume, the top reported reactions are: Nausea (8,955 reports), Arthralgia (8,661 reports), Pain In Extremity (8,342 reports). These figures reflect FDA adverse event reports and may not represent the true incidence rate of these side effects in all patients taking Teriparatide.

What percentage of Teriparatide adverse event reports are serious?

Out of 111,255 classified reports, 41,183 (37.0%) were classified as serious and 70,072 as non-serious. The FDA classifies an event as "serious" if it results in death, hospitalization, disability, or other medically significant outcomes. A higher serious-event ratio warrants closer attention but does not necessarily mean the drug is unsafe.

Who reports adverse events for Teriparatide (by sex)?

Adverse event reports for Teriparatide break down by patient sex as follows: Female: 99,358, Male: 10,240, Unknown: 40. This distribution reflects reporting patterns rather than actual risk differences between groups. Reporting rates can be influenced by prescribing patterns, disease demographics, and reporting behavior.

What age groups report the most side effects for Teriparatide?

The most frequently reported age groups for Teriparatide adverse events are: age 75: 2,734 reports, age 76: 2,047 reports, age 77: 2,033 reports, age 78: 1,990 reports, age 79: 1,964 reports. Age-related reporting patterns can reflect both the demographics of the patient population and potential age-related susceptibility to certain side effects.

Who manufactures Teriparatide?

The primary manufacturer associated with Teriparatide adverse event reports is Eli Lilly And Company. Multiple manufacturers may produce generic versions of this drug. The manufacturer listed reflects the most frequently reported brand in FDA adverse event data.

What other side effects have been reported for Teriparatide?

Beyond the most common reactions, other reported adverse events for Teriparatide include: Pain, Fatigue, Back Pain, Muscle Spasms, Malaise. Less common side effects can still be clinically significant. Patients should report any unusual symptoms to their healthcare provider.

How do I report a side effect from Teriparatide?

You can report adverse events from Teriparatide to the FDA through their MedWatch program at www.fda.gov/medwatch, by calling 1-800-FDA-1088, or by completing Form FDA 3500. Healthcare professionals, consumers, and manufacturers can all submit reports. Reporting helps the FDA monitor drug safety after approval.

What is Teriparatide's safety score and what does it mean?

Teriparatide has a safety concern score of 55 out of 100 (elevated concern). This score is calculated from the ratio of serious to non-serious adverse events, the diversity of reported reactions, and the overall volume of reports relative to usage. The most common reactions are nausea, arthralgia, and pain in extremity, indicating a high incidence of musculoskeletal discomfort.

What are the key safety signals for Teriparatide?

Key safety signals identified in Teriparatide's adverse event data include: Falls and fractures are reported, which could be related to the drug's mechanism of action on bone density.. Increased blood calcium levels are noted, suggesting a risk of hypercalcemia.. Death reports are present, though not frequent, indicating a need for careful monitoring.. These signals are derived from patterns in FDA reports and should be discussed with a healthcare provider for personalized assessment.

Does Teriparatide interact with other drugs?

Teriparatide can cause injection site reactions, and patients should be monitored for signs of hypercalcemia and other serious adverse events. Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking before starting Teriparatide.

What should patients know before taking Teriparatide?

Patients should report any unusual symptoms to their healthcare provider immediately. Proper administration techniques should be followed to minimize injection site reactions.

Are Teriparatide side effects well-documented?

Teriparatide has 227,333 adverse event reports on file with the FDA. Serious adverse events, such as falls and death, are reported but at a lower rate compared to non-serious events. The volume of reports for Teriparatide reflects both the drug's usage level and the vigilance of the reporting community.

What is the FDA's position on Teriparatide?

The FDA continues to monitor teriparatide for safety, and updates will be provided as necessary based on ongoing reviews. For the most current regulatory information, check the FDA's drug labeling database or consult your pharmacist.

Related Drugs

Drugs related to TERIPARATIDE based on therapeutic use, drug class, or shared indications:

AlendronateRisedronateIbandronate
Important Disclaimer: This content is generated by AI analysis of FDA adverse event reports and is provided for informational purposes only. It is not medical advice. Adverse event reports submitted to the FDA do not prove that a medication caused the reported side effect. Always consult your healthcare provider before starting, stopping, or changing any medication. If you experience a serious side effect, contact your doctor or call 911 immediately.